MLB Betting: Greg Peterson’s Top Picks for Saturday, April 4

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Published: April 4, 2026 2:46 PM ET

MLB Betting: Greg Peterson’s Top Picks for Saturday, April 4

Expert baseball analyst Greg Peterson shares his top picks for MLB betting on Saturday, April 4. In this article, we highlight key matchups and insights to help bettors make informed decisions.

Cardinals vs. Tigers

The St. Louis Cardinals face the Detroit Tigers in an afternoon matchup at 1:10 PM Eastern. Both teams struggled on the mound during their previous season. Cardinals pitcher Dustin May had a 4.96 ERA, while Tigers pitcher Jack Flaherty posted a 4.64 ERA. Both bullpens also faced challenges, ranking 21st and 22nd in ERA.

Pick: Over 7.5 Runs (Greg’s Handicapped Total 8.3)

Dodgers vs. Nationals

At 4:05 PM Eastern, the Los Angeles Dodgers take on the Washington Nationals. The Dodgers recently exploded for 13 runs but had an inconsistent start to the season. They face Nationals pitcher Jake Irvin, who struggled last season with a 5.70 ERA.

Pick: Under 9.5 Runs (Greg’s Handicapped Total 8.9)

Orioles vs. Pirates

The Baltimore Orioles are set to meet the Pittsburgh Pirates. Pirates pitcher Carmen Mlodzinski had a 3.55 ERA, predominantly as a reliever, but faced difficulties as a starter. Orioles pitcher Shane Baz struggled in 2025 with a 4.87 ERA but shows potential based on strikeout statistics.

Pick: Orioles Moneyline -115 (Greg’s Handicap Orioles -129)

Padres vs. Red Sox

In an evening game, the San Diego Padres square off against the Boston Red Sox. Padres pitcher Randy Vasquez had a mixed season, while Red Sox debutant Connelly Early has shown impressive numbers with a 2.19 ERA in limited starts.

Pick: Red Sox Moneyline -136
Over 8 Runs (Greg’s Handicap Red Sox -165 and Total 9.1)

Rays vs. Twins

The Tampa Bay Rays will meet the Minnesota Twins at 7:10 PM Eastern. Rays pitcher Steven Matz is coming off an exceptional season, whereas Twins pitcher Mick Abel faced struggles with a 6.23 ERA in his initial appearance this season.

Pick: Rays Moneyline +105
Over 7.5 Runs (Greg’s Handicap Rays -133 and Total 8.1)

Brewers vs. Royals

In a doubleheader, the Milwaukee Brewers challenge the Kansas City Royals. Brewers pitcher Brandon Sproat had a tough debut, while Royals pitcher Seth Lugo had a challenging 2025. The Brewers ranked fifth in overall scoring but struggled with home runs.

Pick: Royals Moneyline -118
Over 8.5 Runs (Game 2 of the Doubleheader, Greg’s Handicap Royals -152 and Total 9.2)

Braves vs. Diamondbacks

The Atlanta Braves face off against the Arizona Diamondbacks in another critical matchup. Braves pitcher Bryce Elder endured a rough season, while Diamondbacks pitcher Michael Soroka had some misfortune with a 4.52 ERA.

Pick: Diamondbacks Moneyline -105 (Greg’s Handicap Diamondbacks -118)

Cubs vs. Guardians

Lastly, the Chicago Cubs take on the Cleveland Guardians. Guardians pitcher Slade Cecconi had a shaky debut, while Cubs pitcher Shota Imanaga displayed a strong performance last season.