Greg Peterson’s Top MLB Picks for Saturday, April 11

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Published: April 11, 2026 1:38 PM ET

Greg Peterson’s Top MLB Picks for Saturday, April 11

Expert baseball handicapper Greg Peterson has revealed his top MLB picks for Saturday, April 11. Fans and bettors are encouraged to analyze the matchups and statistics before placing wagers.

Key Matchups for April 11

Arizona Diamondbacks vs. Philadelphia Phillies

The game kicks off at 1:05 PM Eastern. The Phillies will start Taijuan Walker, who ended last season with a 4.08 ERA but a 5.07 fielding independent pitching rating. He allowed 1.5 home runs and issued 3.1 walks per nine innings. In contrast, Diamondbacks pitcher Brandon Pfaadt posted a 5.23 ERA with a career-low of 7.5 strikeouts per nine innings. The Diamondbacks ranked fourth in scoring with an average of 4.9 runs per game, while the Phillies were third at 5.3 runs per game.

Pick: Diamondbacks vs. Phillies Over 8.5 Runs (Greg’s Handicapped Total 9.2)

Miami Marlins vs. Detroit Tigers

Scheduled for 1:10 PM Eastern, the Marlins will send Janson Junk to the mound. Junk had a 4.17 ERA with strong command, allowing only 0.7 home runs per nine innings despite low strikeout rates. Tigers pitcher Casey Mize had a 3.87 ERA and faced a Marlins lineup that struggled in hitting home runs, ranking 27th in the league.

Pick: Tigers Moneyline -134 (Greg’s Handicap Tigers -166)

Pittsburgh Pirates vs. Chicago Cubs

Starting at 2:20 PM Eastern, Cubs pitcher Edward Cabrera had a stellar 2025 season with a 3.53 ERA and high strikeout rate of 9.8 per nine innings. Meanwhile, Pirates pitcher Braxton Ashcraft posted a notable 2.64 ERA since his MLB debut. Despite improvements, the Pirates were last in scoring last season.

Pick: Cubs Moneyline -134 and Over 6.5 Runs (Greg’s Handicap Cubs Moneyline -165 and Total 7.9)

Minnesota Twins vs. Toronto Blue Jays

This match starts at 3:07 PM Eastern. Blue Jays pitcher Eric Lauer had a solid 2025 season and led the league in limiting walks. The Twins’ Joe Ryan maintained a respectable 3.42 ERA but struggled with home runs on the road.

Pick: Blue Jays Moneyline -105 and Over 7.5 Runs (Greg’s Handicap Blue Jays -136 and Total 8.4)

Oakland Athletics vs. New York Mets

Starting at 4:10 PM Eastern, the Athletics will send Jacob Lopez to pitch. The Mets’ Kodai Senga has shown promise with a high strikeout rate early in the season. Both teams look to capitalize on their opponent’s weaker bullpens, especially the Athletics, which ranked 24th in ERA last season.

Pick: Mets Run Line -1.5 +145 and Over 7.5 Runs (Greg’s Handicap Mets -1.5 +102 and Total 8.1)

Los Angeles Angels vs. Cincinnati Reds

This matchup begins at 4:15 PM Eastern. Angels pitcher George Klassen is making only his second career start, while Brandon Williamson returns after a lengthy absence due to injury. Both teams have fluctuating performance statistics and less-than-stellar bullpens from last season.

Pick: Reds Moneyline -125 and Over 9 Runs (Greg’s Handicap Reds -176 and Total 9.6)

Washington Nationals vs. Milwaukee Brewers

Scheduled for 7:10 PM Eastern, Brewers starter Kyle Harrison had a 4.04 ERA last season, while Nationals pitcher Foster Griffin returns to the league with a promising start. Both teams endured struggles with their bullpens last season but hope for better outcomes.

Pick: Brewers Run Line -1.5 +135 and Over 7.5 Runs (Greg’s Handicap Brewers -1.5 +105 and Total 8.4)

San Francisco Giants vs. Baltimore Orioles

This clash begins at 7:15 PM Eastern. Giants pitcher Logan Webb excels at home, while Chris Bassitt of the Orioles has had a rough start to the season. Expectations for this matchup revolve around pitching performance and historical trends.

Pick: Giants vs. Orioles Over 7.5 Runs (Greg’s Handicapped Total 8.3)

Colorado Rockies vs. San Diego Padres

This game kicks off at 8:40 PM Eastern. Padres pitcher Germán Márquez has faced struggles in the past but benefits from a solid bullpen. The Rockies remain a challenge in road scoring, which heavily impacts their performance outlook.

Pick: Rockies vs. Padres Under 8.5 Runs (Greg’s Handicapped Total 7.9)

Houston Astros vs. Seattle Mariners

Starting at 9:40 PM Eastern, Mariners pitcher Luis Castillo has shown improvements at home, whereas the Astros’ Lance McCullers Jr. continues to face challenges after a long recovery. The game is critical for both teams as they seek early-season momentum.