Joey Cantillo is set to start for the Cleveland Guardians against the Houston Astros on Saturday night in Houston, with first pitch scheduled for 7:15 p.m. ET on Saturday, June 20, 2026. The matchup comes after the Astros won the opener 9-3 on Friday night, a result that kept them moving with three straight wins.
Joey Cantillo and Houston
Cantillo enters with a 5-3 record and a 4.38 ERA. In his last start, he allowed one run on six hits in five innings against the Detroit Tigers, and the Guardians won that game 3-1. That outing gives Cleveland a useful recent line to build on as it tries to respond after Friday’s loss.
Spencer Arrighetti for the Astros
Houston will counter with Spencer Arrighetti, who is 7-2 with a 2.57 ERA. The Astros have won nine of his last 11 starts this season, a run that lines up with their current position in fourth place in the AL West at 36-41.
The standings pressure runs both ways. The Guardians are 40-36 and in a first-place tie in the AL Central, but they have lost three of their last four games. Houston is three games back of the Seattle Mariners, so the margin behind them remains tight enough that one series can still move the picture.
For Cleveland, the practical edge is simple: Cantillo has already shown he can work five clean innings with limited damage, and now he gets the same opponent on the road in Houston. For Houston, Arrighetti’s numbers and the club’s three-game winning streak give the Astros a chance to push the series further in their favor before the weekend turns again.
