Week 12 College Football: Predicting Five Major Upsets in 2025 Season

Week 12 of the college football season promises excitement with predictions of five significant upsets. This analysis aims to identify potential surprises as teams battle for dominance in the field.

Predictions for Major Upsets in Week 12

• Arkansas vs. LSU

  Arkansas is coming off a bye week, aiming for its first SEC win. Having narrowly lost to Mississippi State due to a record-breaking 193 penalty yards, the Razorbacks are set to face LSU. The Tigers recently suffered a 20-9 loss to Alabama, showcasing a struggling offense. Michael Van Buren will start for LSU, adding unpredictability to the matchup.

  Pick: Arkansas +180 (BetMGM)

• Oklahoma vs. Alabama

  Oklahoma returns from a bye against an Alabama team struggling on offense. The Crimson Tide has failed to achieve above-average offensive outputs since October 18. Oklahoma boasts one of the top defenses nationwide, putting pressure on Alabama’s Ty Simpson.

  Pick: Oklahoma +180 (bet365)

• Mississippi State vs. Mizzou

  Mississippi State aims to secure bowl eligibility under coach Jeff Lebby. After a tough outing against Georgia, they face Mizzou, which will be on its third-string quarterback. The Tigers have little motivation left in the season, especially after a devastating loss to Texas A&M.

  Pick: Mississippi State +225 (DraftKings)

• Virginia vs. Duke

  Virginia looks to make a mark against Duke, which has struggled throughout the season. Despite being overhyped previously, Virginia has a chance to bounce back. With uncertainties surrounding quarterback Chandler Morris’s health, the Cavaliers might capitalize on a favorable line.

  Pick: Virginia +195 (DraftKings)

• Michigan State vs. Penn State

  Michigan State, at 3-6 this season, needs to win out for bowl eligibility. Facing a formidable Penn State team that has shown inconsistency, the Spartans are motivated after a strong showing from quarterback Alessio Milivojevic. Penn State comes off another tough loss, which might affect their morale.

  Pick: Michigan State +235 (bet365)

These matchups reflect a blend of motivation, player health, and historical performance, indicating the potential for upsets in Week 12 of college football. Sports fans should keep an eye on these games as teams vie for vital victories in the 2025 season.