Week 11 2025 NFL Picks: Florio Challenges Simms

In Week 11 of the 2025 NFL season, two analysts, Florio and Simms, offer their insights and predictions on a series of compelling matchups. Their results from the previous week ended in a tie with both finishing at 10-4. The analysts diverge on seven spread outcomes this week, with Florio holding a narrow edge in straight-up predictions, leading 99-49-1 compared to Simms at 98-50-1.

Key Matchups for Week 11

This week features several intriguing matchups, including the following:

Jets at Patriots (-12.5)

• Florio’s Prediction: Patriots 30, Jets 20
• Simms’s Prediction: Patriots 27, Jets 10

Commanders vs. Dolphins (-2.5) at Madrid

• Florio’s Prediction: Dolphins 23, Commanders 20
• Simms’s Prediction: Dolphins 24, Commanders 17

Panthers at Falcons (-3.5)

• Florio’s Prediction: Falcons 23, Panthers 17
• Simms’s Prediction: Falcons 23, Panthers 20

Buccaneers at Bills (-5.5)

• Florio’s Prediction: Bills 27, Buccaneers 24
• Simms’s Prediction: Bills 28, Buccaneers 24

Chargers (-3) at Jaguars

• Florio’s Prediction: Chargers 24, Jaguars 17
• Simms’s Prediction: Chargers 30, Jaguars 20

Bears at Vikings (-3)

• Florio’s Prediction: Vikings 24, Bears 23
• Simms’s Prediction: Vikings 27, Bears 23

Packers (-7) at Giants

• Florio’s Prediction: Packers 24, Giants 20
• Simms’s Prediction: Packers 28, Giants 17

Bengals at Steelers (-5.5)

• Florio’s Prediction: Steelers 28, Bengals 20
• Simms’s Prediction: Steelers 27, Bengals 21

Texans (-6.5) at Titans

• Florio’s Prediction: Texans 17, Titans 13
• Simms’s Prediction: Texans 24, Titans 9

49ers (-3) at Cardinals

• Florio’s Prediction: 49ers 30, Cardinals 13
• Simms’s Prediction: 49ers 31, Cardinals 27

Seahawks at Rams (-3)

• Florio’s Prediction: Rams 30, Seahawks 24
• Simms’s Prediction: Rams 32, Seahawks 28

Ravens (-7.5) at Browns

• Florio’s Prediction: Ravens 21, Browns 17
• Simms’s Prediction: Ravens 28, Browns 13

Chiefs (-3.5) at Broncos

• Florio’s Prediction: Chiefs 24, Broncos 17
• Simms’s Prediction: Chiefs 23, Broncos 20

Lions at Eagles (-2.5)

• Florio’s Prediction: Lions 27, Eagles 23
• Simms’s Prediction: Lions 20, Eagles 17

Cowboys (-3.5) at Raiders

• Florio’s Prediction: Cowboys 31, Raiders 20
• Simms’s Prediction: Cowboys 24, Raiders 20

As the season progresses, fans will closely follow these predictions and game outcomes. The analysts continue to provide contrasting opinions on spreads and scores, adding excitement to an already thrilling NFL season.