Week 12 NFL 2025: Score Predictions and Picks for Every Game
This week, the NFL season reaches its 12th round, bringing exciting matchups and tight competition as teams aim for playoff spots. Various teams will compete for supremacy in their divisions, creating a thrilling atmosphere for fans and players alike. The Kansas City Chiefs, in particular, face challenges as they approach the end of November with the possibility of falling below .500.
Week 12 NFL 2025: Key Matches and Predictions
This week features notable games, including divisional rivalries and critical contests that could impact postseason aspirations. Below, we highlight the upcoming matches along with score predictions and team analyses.
Teams on a Bye
- Denver Broncos
- Washington Commanders
- Miami Dolphins
- Los Angeles Chargers
Buffalo Bills vs. Houston Texans
Date: Thursday, November 20, 2025
Time: 8:15 PM ET
The Buffalo Bills (7-3) are set to visit the Houston Texans (5-5) in a pivotal matchup. After a remarkable performance against the Tampa Bay Buccaneers, quarterback Josh Allen showcased his MVP credentials with a total of six touchdowns in that game. Despite concerns surrounding the Bills’ defense, their momentum positions them favorably against the Texans.
Houston is hoping for the return of quarterback CJ Stroud, who has missed time due to a concussion. His expected participation may impact the game’s outcome, but the Texans also face considerable challenges. They possess the league’s top defense in terms of yardage allowed but rank 28th in red zone efficiency, which could spell trouble against a resurgent Buffalo offense.
Game Analysis and Prediction
The Bills enter as 3.5-point favorites, bolstered by their recent performance. Houston’s defense aims to keep them competitive, but their struggles in critical moments could prove detrimental. If Stroud returns, it might not be enough to secure a win, especially given Allen’s current form.
Prediction: Buffalo Bills win 24-20
As Week 12 unfolds, fans can anticipate high-stakes football that embodies the excitement and unpredictability of the NFL. Each game carries weight as teams fight for position heading into the playoff window.
