Bills vs. Texans: Expert Picks, Odds, and Predictions for Thursday Night Football

The upcoming matchup between the Buffalo Bills and Houston Texans on November 20, 2025, promises to be an electrifying clash. Kickoff is set for 8:15 p.m. ET at NRG Stadium in Houston, Texas, and the game will be broadcast on Amazon Prime Video. The Bills, boasting a record of 7-3, are favored by 5.5 points against the Texans, who stand at 5-5. The over/under for total points is established at 43.5.

Bills vs. Texans: Key Player Insights

The Buffalo Bills’ success largely hinges on the prowess of their quarterback, Josh Allen. Allen has thrown for 2,456 yards this season, with 18 touchdowns and seven interceptions. His dual-threat capability, complemented by 351 rushing yards, makes him a formidable opponent. Supporting him, running back James Cook averages 96.8 rushing yards per game, ranking second in the NFL with a total of 968 yards and seven rushing touchdowns.

On the defensive end, Cole Bishop leads the Bills with 54 tackles and three interceptions. The strength of the Bills’ defense includes Joey Bosa, who has recorded four sacks this season.

Texans’ Challenges and Standouts

The Texans enter this game with a strong defensive reputation, allowing only 16.3 points per game. However, they face difficulties due to injuries. Starting quarterback C.J. Stroud is sidelined due to a concussion, which puts backup Davis Mills in the spotlight. Mills has shown promise, averaging 283 passing yards over his last two starts.

Houston’s offensive threats include Nico Collins, who has 49 receptions for 642 yards and four touchdowns. Furthermore, the Texans’ defense is anchored by Danielle Hunter, who has recorded nine sacks this season, ranking among the NFL leaders.

Matchup History and Betting Insights

• Houston has outperformed Buffalo recently, holding a 3-1 record in their last four meetings.
• This season, the Bills have a 5-5 record against the spread, while the Texans are 4-6.
• Bookmakers give the Texans a 32.3% chance to win based on odds.

Predictions and Expected Performance

Analysts predict that the Bills will leverage their offensive strengths to overpower the Texans. Despite Houston’s formidable defense, the absence of key players may hinder their performance. The Bills are expected to capitalize, particularly with their running game against Houston’s defensive vulnerabilities.

The final prediction suggests a score of Bills 24, Texans 17, aligning with expectations for a competitive and thrilling Thursday Night Football encounter.