Florio vs. Simms: NFL Week 16 Picks for 2025

As the NFL regular season approaches its climax, Week 16 presents exciting matchups and predictions. Analysts Florio and Simms have offered their insights, with a growing competition between them for the best record.

Current Standings

At the moment, Simms leads with a record of 148 wins, 75 losses, and 1 tie, while Florio trails slightly with 145 wins, 78 losses, and 1 tie. In their bets against the spread, Simms is 111-110-3, while Florio stands at 120-101-3.

Key Matchups for Week 16

• Rams at Seahawks (-1.5)

  Florio predicts a close game, with the Seahawks winning 27-24, while Simms expects a tighter result of 23-20.

• Eagles (-6.5) at Commanders

  This game marks a potential championship day, with Florio picking the Eagles to win 30-17 against Simms’ prediction of 30-20.

• Packers at Bears (-1.5)

  Florio sees the Bears winning 24-20, while Simms thinks it will be 24-21.

• Buccaneers (-3) at Panthers

  With high stakes for coach Todd Bowles, Florio chooses the Buccaneers 23-17, while Simms predicts a Panthers victory at 27-24.

• Bills (-10.5) at Browns

  Josh Allen’s performance is crucial. Florio estimates a win for the Bills at 31-20, compared to Simms’ prediction of 20-9.

• Chargers at Cowboys (-2.5)

  Both analysts expect the Chargers to come out on top, with a score of 24-20.

• Bengals (-4.5) at Dolphins

  Florio takes the Dolphins 27-23, while Simms predicts a Bengals victory, 21-17.

• Jets at Saints (-4.5)

  With new strategies in place, Florio predicts a Saints win at 27-17, while Simms goes for a narrower 23-13.

• Vikings (-3) at Giants

  Florio expects the Vikings to finish strong, predicting a 28-13 win over Simms’ 27-17 pick.

• Chiefs (-3) at Titans

  Both analysts predict a tight game, with Florio favoring the Titans 20-17 and Simms opting for the Chiefs 16-10.

• Falcons (-3) at Cardinals

  Florio picks the Cardinals to edge the Falcons 24-21, while Simms anticipates a 27-21 win for Atlanta.

• Jaguars at Broncos (-3)

  Expecting a close contest, Florio chooses the Broncos at 27-23, while Simms predicts the Jaguars will win the match 27-24.

• Steelers at Lions (-7)

  Florio analyzes a crucial game, forecasting a Lions win at 29-21 over Simms’ predicted 34-21 score.

• Raiders at Texans (-14.5)

  Despite a possible letdown, Florio believes the Texans will win 34-20, contrasting with Simms’ prediction of 27-9.

• Patriots at Ravens (-3)

  Looking for redemption, Florio picks the Patriots 27-23 compared to Simms’ call of 24-20 for New England.

• 49ers (-6.5) at Colts

  Florio anticipates a straightforward victory for the 49ers at 27-20, while Simms sees a stronger win at 28-13.

Conclusion

As both experts make their selections for NFL Week 16, the competition remains tight. Fans will certainly be keeping close tabs on these games and outcomes as the season draws to a close.