Toxic ‘Forever Chemicals’ May Accelerate Aging in Men Over 50
Recent research highlights a potential link between exposure to toxic “forever chemicals,” known as PFAS, and accelerated aging in men aged 50 to 65. These perfluoroalkyl and polyfluoroalkyl substances are prevalent in the bloodstream of about 98% of Americans, according to the National Academies of Sciences, Engineering, and Medicine.
Impact of PFAS on Aging
The study, conducted by researchers at Shanghai Jiao Tong University, indicates that men in this age group may experience advanced epigenetic aging, a measure of biological age rather than chronological age. Senior study author Xiangwei Li noted that the strongest associations were observed in middle-aged men, with younger men and those over 65 showing weaker and less statistically significant links.
Key Findings
- The most significant effects were found in men between 50 and 65 years old.
- Women also exhibited some association, though it was less pronounced than in men.
- PFAS exposure may lower testosterone levels and impair sperm quality in men.
- Health risks linked to PFAS include cancers, fertility issues, and hormone disruptions.
Jane Muncke, managing director of the Food Packaging Forum, remarked on the study’s implications. “This points to a sex-specific effect of chemicals disrupting the endocrine system, crucial for regulating functions like growth and metabolism.”
Understanding PFAS Chemistry
PFAS compounds are utilized for their nonstick and oil- and water-repellent properties since the 1950s. Health studies have consistently associated these chemicals with serious health issues including cancer, liver damage, and thyroid disease. The study notably targeted legacy PFAS like PFOS and PFOA, which have faced international regulatory scrutiny.
Study Methodology
Published in the journal Frontiers in Aging, this research analyzed data from 326 participants enrolled in the National Health and Nutrition Examination Survey between 1999 and 2000. Researchers examined blood samples for 11 types of PFAS, focusing on how these chemicals impacted the DNA methylome, a critical epigenetic marker.
Regulatory Response and Public Health
The American Chemistry Council criticized the study for its exploratory nature and small sample size, arguing it does not establish causation. Despite this, the findings suggest that PFAS may biologically impact aging, especially in older men.
With increasing awareness, the U.S. EPA under the Biden administration had plans to enforce stricter PFAS guidelines. However, progress has stalled, and many PFAS variants remain under-researched. Li emphasized the importance of reducing exposure through practical means, such as using water filters and avoiding contact with certain materials.
As studies continue, it remains vital to address PFAS exposure and its implications for health, particularly for aging populations. The presence of these chemicals in everyday life poses significant challenges for public health and safety.
