Greg Peterson’s Top MLB Picks for Friday, April 17

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Published: April 17, 2026 12:50 PM ET

Greg Peterson’s Top MLB Picks for Friday, April 17

Greg Peterson, a noted expert in baseball betting, provides his top MLB picks for Friday, April 17. His insights are vital for bettors looking to make informed decisions.

Top MLB Picks for April 17

Baltimore Orioles vs. Cleveland Guardians

The Orioles will face the Guardians at 6:10 PM Eastern. Baltimore’s Chris Bassitt has struggled early, allowing 11 earned runs over 11 innings. Cleveland’s Tanner Bibee has also faced challenges, holding a 6.38 ERA this season. However, Bibee has performed better at home in the past.

Pick: Guardians Moneyline -130
Greg’s Handicap: Guardians -150

San Francisco Giants vs. Washington Nationals

The Giants take on the Nationals at 6:45 PM Eastern. San Francisco’s Logan Webb has a significant home advantage with a 2.90 ERA at home. The Nationals’ Zack Littell, with a 4.20 ERA this season, has allowed five home runs in just 15 innings.

Pick: Giants vs. Nationals Over 8 Runs
Greg’s Handicap: Total 9.1

Tampa Bay Rays vs. Pittsburgh Pirates

This matchup begins at 7:10 PM Eastern. Bubba Chandler of the Pirates has shown potential with a 3.97 ERA. In contrast, Rays starter Nick Martinez pitches to contact with limited strikeouts.

Pick: Rays vs. Pirates Under 8.5 Runs
Greg’s Handicap: Total 7.8

Kansas City Royals vs. New York Yankees

The game starts at 7:05 PM Eastern. Yankees pitcher Cam Schlittler has impressed with a 2.85 ERA. Royals pitcher Michael Wacha, although currently boasting a low ERA, could face regression based on underlying metrics.

Pick: Yankees Run Line -1.5 +125
Greg’s Handicap: Yankees -1.5 +106

Detroit Tigers vs. Boston Red Sox

At 7:15 PM Eastern, both teams are underperforming compared to last season. Tigers pitcher Casey Mize has a 3.94 ERA while Boston’s Ranger Suarez has a higher 5.02 ERA and fewer strikeouts.

Pick: Tigers vs. Red Sox Over 8 Runs
Greg’s Handicap: Total 8.4

Cincinnati Reds vs. Minnesota Twins

The game commences at 8:10 PM Eastern. Reds’ Brandon Williamson has struggled this season, with a 5.28 ERA but showed improvement in his last two starts. Twins’ Joe Ryan has a solid 3.80 ERA with a strong fielding independent number.

Pick: Reds vs. Twins Under 8 Runs
Greg’s Handicap: Total 7.4

Chicago White Sox vs. Athletics

Starting at 9:40 PM Eastern, the Athletics have the worst home ERA in the American League. White Sox pitcher Davis Martin holds a 4.10 ERA but faces a challenging lineup.